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Distribution. After administration, therapeutic concentrations of amoxicillin and clavulanic acid are observed in tissues and interstitial fluid. Therapeutic concentrations of both substances are found in the gall bladder, abdominal tissues, skin, adipose and muscle tissues; as well as in synovial and peritoneal fluids, bile and pus. Amoxicillin and clavulanic acid weakly bind to proteins; In studies, it was found that protein binding indices account for 25% for clavulanic acid and 18% for amoxicillin of their total plasma concentrations.